Extract the gist of your genome.

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Supports: 23andMe (.txt)

Your file stays on your device — never uploaded or shared

What is this?

GenomeGist extracts clinically and wellness-relevant genetic variants (SNPs) from raw genome files exported from services like 23andMe. The output is a compact file ready for analysis with AI tools like ChatGPT or Claude.

What are SNPs?

SNPs (single nucleotide polymorphisms, pronounced "snips") are small genetic variations that make you unique. Your genome file from 23andMe contains data on hundreds of thousands of these variants. Most are unremarkable, but some are associated with health traits, drug metabolism, or nutritional needs.

GenomeGist extracts just the variants that researchers have linked to meaningful traits, filtering out the noise so you can focus on what matters.

How to use the output

The extracted file is designed to be uploaded to AI assistants for personalized analysis. You can:

  • Ask about specific variants and what they mean
  • Get personalized supplement or nutrition suggestions based on your genetics
  • Understand how you might respond to certain medications
  • Learn about your genetic predispositions for various health traits

The compact output format keeps the file small enough to upload without hitting context limits, while including enough information for meaningful analysis.

What's Included

Free

Demo Report

~15 variants

A sample of well-known SNPs including MTHFR, APOE, COMT, and a few others. Great for trying out the tool.

Full Access

Complete Report

1,000+ variants

Comprehensive coverage across all categories. Process as many files as you like with unlimited exports for 24 hours.

$19.99

Categories in Full Report

The complete report covers these categories. Select Wellness for lifestyle optimization, or Full Report to include all.

Methylation

MTHFR and related genes affecting folate metabolism and homocysteine levels. Relevant for B-vitamin supplementation.

Nutrition

Vitamin D metabolism, lactose tolerance, obesity risk factors, and caffeine sensitivity.

Neurotransmitters

COMT, BDNF, and dopamine-related variants affecting mood, focus, and stress response.

Drug Response

CYP2C19, CYP2D6, and other genes affecting how you metabolize medications. Important for personalized medicine.

Cardiovascular

APOE and other markers associated with heart health and lipid metabolism.

Detoxification

Genes involved in clearing toxins and environmental compounds from your body.

Immune

Immune system function and inflammation markers that may affect health outcomes.

Frequently Asked Questions

How do I get my genome file?

If you've done a DNA test with 23andMe, you can download your raw data from their website. Go to Settings > Privacy > Download Your Data. The file will be a .txt file containing your genetic data.

Is my data safe?

Yes. All processing happens locally in your browser. Your genome file is never uploaded to any server. The only network requests this tool makes are to load the application itself and the SNP reference list.

The source code is publicly available for review. You can audit the code yourself or run it locally.

What AI tools work with the output?

The output file works with any AI assistant that accepts file uploads: ChatGPT, Claude, Google Gemini, and others. The "Compact" format is optimized for AI context limits, keeping the file small while retaining essential information.

Why are some variants marked "no-call"?

A "no-call" means the genotyping array couldn't reliably determine your genotype at that position. This can happen due to sample quality or technical limitations. These variants are included but marked so you know the data is uncertain.

What's the difference between Wellness and Full Report?

Wellness Only includes nutrition, methylation, neurotransmitter, and detoxification variants — useful for lifestyle optimization. Full Report adds pharmacogenomics (drug response), cardiovascular, and immune markers, which have more direct medical implications.

Can I use this for medical decisions?

No. This tool is for educational and research purposes only. Genetic variants are just one factor in health outcomes. Always consult a healthcare provider or genetic counselor for medical advice.

Privacy

Your genetic data never leaves your browser. All processing happens locally on your device. We don't upload, store, or transmit your genome file. The only network requests are for loading the application itself.

The source code is publicly available. You can audit the code to verify these claims, or run it locally on your own machine.

Pricing

Free Demo

Try the tool with ~15 common SNPs

$0

Full Access

1,000+ variants across all categories

$19.99

Full Access includes 3 sessions. Each session gives you 24 hours of unlimited access — process multiple files, export with any settings, as many times as you need.

Disclaimer

This tool is for research and educational purposes only. The information provided is NOT medical advice. Genetic variants may have different effects depending on other genetic and environmental factors.

Consult a healthcare provider or genetic counselor for interpretation of genetic data. The annotations are derived from public databases (ClinVar, PharmGKB, SNPedia) and may not reflect the most current scientific understanding.

GenomeGist does not diagnose, treat, cure, or prevent any disease. Do not make health decisions based solely on this information.